Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes

Author(s): Zu Thur Yew, Michael Schlierf, Matthias Rief, and Emanuele Paci<br/>The study of mechanical unfolding, through the combined efforts of atomic force microscopy and simulation, is yielding fresh insights into the free-energy landscapes of proteins. Thus far, experiments have been mostly analyzed with one-dimensional models of the free-energy landscape. We show that as...<br/><img src="" width="30" height="30" alt="Free to Read"/><br/>[Phys. Rev. E 81, 031923] Published Tue Mar 30, 2010